Found 45 hits from Alexandru Ioan Cuza University Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50067584
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189292
(CHEMBL3828157)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2ccccc12 Show InChI InChI=1S/C27H22N2O3S/c1-3-32-27(31)19-17-23(29-15-7-6-8-20(19)29)24(30)14-12-18-11-13-22-26(16-18)33-25-10-5-4-9-21(25)28(22)2/h4-17H,3H2,1-2H3/b14-12+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189293
(CHEMBL3827279)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2c(C)cccc12 Show InChI InChI=1S/C28H24N2O3S/c1-4-33-28(32)20-17-24(30-18(2)8-7-10-21(20)30)25(31)15-13-19-12-14-23-27(16-19)34-26-11-6-5-9-22(26)29(23)3/h5-17H,4H2,1-3H3/b15-13+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189295
(CHEMBL3828384)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2ccc(C)cc12 Show InChI InChI=1S/C28H24N2O3S/c1-4-33-28(32)20-17-24(30-14-13-18(2)15-23(20)30)25(31)12-10-19-9-11-22-27(16-19)34-26-8-6-5-7-21(26)29(22)3/h5-17H,4H2,1-3H3/b12-10+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50059863
((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)Show InChI InChI=1S/C19H34O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17(19(22)23)16(2)18(20)21/h3-15H2,1-2H3,(H,20,21)(H,22,23)/b17-16- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50059863
((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)Show InChI InChI=1S/C19H34O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17(19(22)23)16(2)18(20)21/h3-15H2,1-2H3,(H,20,21)(H,22,23)/b17-16- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189304
(CHEMBL3827991)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(Br)cc2)n2ccc(OC)cc12 Show InChI InChI=1S/C21H18BrNO4/c1-3-27-21(25)17-13-19(23-11-10-16(26-2)12-18(17)23)20(24)9-6-14-4-7-15(22)8-5-14/h4-13H,3H2,1-2H3/b9-6+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 602 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189297
(CHEMBL3828545)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2ccc(OC)cc12 Show InChI InChI=1S/C28H24N2O4S/c1-4-34-28(32)20-17-24(30-14-13-19(33-3)16-23(20)30)25(31)12-10-18-9-11-22-27(15-18)35-26-8-6-5-7-21(26)29(22)2/h5-17H,4H2,1-3H3/b12-10+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 711 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189301
(CHEMBL3827237)Show SMILES COc1cc(\C=C\C(=O)c2ccc3c(C)cc(C)cn23)cc(OC)c1OC Show InChI InChI=1S/C22H23NO4/c1-14-10-15(2)17-7-8-18(23(17)13-14)19(24)9-6-16-11-20(25-3)22(27-5)21(12-16)26-4/h6-13H,1-5H3/b9-6+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 726 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189302
(CHEMBL3827637)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(Cl)cc2)n2ccc(OC)cc12 Show InChI InChI=1S/C21H18ClNO4/c1-3-27-21(25)17-13-19(23-11-10-16(26-2)12-18(17)23)20(24)9-6-14-4-7-15(22)8-5-14/h4-13H,3H2,1-2H3/b9-6+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 931 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50156812
(PHENSTATIN)Show InChI InChI=1S/C17H18O6/c1-20-13-6-5-10(7-12(13)18)16(19)11-8-14(21-2)17(23-4)15(9-11)22-3/h5-9,18H,1-4H3 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
'Al. I. Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of bovine tubulin polymerization preincubated for 30 mins followed by GTP addition measured after 20 mins by spectrophotometric method |
Bioorg Med Chem 24: 2307-17 (2016)
Article DOI: 10.1016/j.bmc.2016.04.001 BindingDB Entry DOI: 10.7270/Q2KW5HX2 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036274
(CHEMBL3361086)Show SMILES Cc1cccc2c(cc(C(=O)c3ccc(Br)cc3)n12)C(=O)OCC#C Show InChI InChI=1S/C20H14BrNO3/c1-3-11-25-20(24)16-12-18(22-13(2)5-4-6-17(16)22)19(23)14-7-9-15(21)10-8-14/h1,4-10,12H,11H2,2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189300
(CHEMBL3826996)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(cc2)-c2ccccc2)n2ccc(OC)cc12 Show InChI InChI=1S/C27H23NO4/c1-3-32-27(30)23-18-25(28-16-15-22(31-2)17-24(23)28)26(29)14-11-19-9-12-21(13-10-19)20-7-5-4-6-8-20/h4-18H,3H2,1-2H3/b14-11+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036270
(CHEMBL3361094)Show SMILES Cc1cccc2c(cc(C(=O)c3ccc(Br)cc3)n12)C(=O)OCCC#C Show InChI InChI=1S/C21H16BrNO3/c1-3-4-12-26-21(25)17-13-19(23-14(2)6-5-7-18(17)23)20(24)15-8-10-16(22)11-9-15/h1,5-11,13H,4,12H2,2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189303
(CHEMBL3828130)Show SMILES COc1ccn2c(cc(C(O)=O)c2c1)C(=O)\C=C\c1ccc(Cl)cc1 Show InChI InChI=1S/C19H14ClNO4/c1-25-14-8-9-21-16(10-14)15(19(23)24)11-17(21)18(22)7-4-12-2-5-13(20)6-3-12/h2-11H,1H3,(H,23,24)/b7-4+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035931
(CHEMBL3361085)Show SMILES Cc1cccc2c(cc(C(=O)c3ccc(Cl)cc3)n12)C(=O)OCC#C Show InChI InChI=1S/C20H14ClNO3/c1-3-11-25-20(24)16-12-18(22-13(2)5-4-6-17(16)22)19(23)14-7-9-15(21)10-8-14/h1,4-10,12H,11H2,2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036277
(CHEMBL3361077)Show InChI InChI=1S/C19H13BrN2O2/c1-2-10-21-19(24)15-12-17(22-11-4-3-5-16(15)22)18(23)13-6-8-14(20)9-7-13/h1,3-9,11-12H,10H2,(H,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498791
(CHEMBL3623716)Show SMILES OC(=O)[C@H](CS)NC(=O)CCN1c2ccccc2Sc2ccccc12 |r| Show InChI InChI=1S/C18H18N2O3S2/c21-17(19-12(11-24)18(22)23)9-10-20-13-5-1-3-7-15(13)25-16-8-4-2-6-14(16)20/h1-8,12,24H,9-11H2,(H,19,21)(H,22,23)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036276
(CHEMBL3361076)Show InChI InChI=1S/C19H13ClN2O2/c1-2-10-21-19(24)15-12-17(22-11-4-3-5-16(15)22)18(23)13-6-8-14(20)9-7-13/h1,3-9,11-12H,10H2,(H,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036272
(CHEMBL3361092)Show InChI InChI=1S/C21H17NO3/c1-3-4-13-25-21(24)17-14-19(20(23)16-10-6-5-7-11-16)22-15(2)9-8-12-18(17)22/h1,5-12,14H,4,13H2,2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189299
(CHEMBL3828274)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(cc2)C#N)n2ccc(OC)cc12 Show InChI InChI=1S/C22H18N2O4/c1-3-28-22(26)18-13-20(24-11-10-17(27-2)12-19(18)24)21(25)9-8-15-4-6-16(14-23)7-5-15/h4-13H,3H2,1-2H3/b9-8+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035927
(CHEMBL3361080)Show SMILES Cc1cccc2c(cc(C(=O)c3ccc(Br)cc3)n12)C(=O)NCC#C Show InChI InChI=1S/C20H15BrN2O2/c1-3-11-22-20(25)16-12-18(23-13(2)5-4-6-17(16)23)19(24)14-7-9-15(21)10-8-14/h1,4-10,12H,11H2,2H3,(H,22,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189294
(CHEMBL3827132)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2cc(OC)c(OC)c(OC)c2)n2ccc(OC)cc12 Show InChI InChI=1S/C24H25NO7/c1-6-32-24(27)17-14-19(25-10-9-16(28-2)13-18(17)25)20(26)8-7-15-11-21(29-3)23(31-5)22(12-15)30-4/h7-14H,6H2,1-5H3/b8-7+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498787
(CHEMBL3623718)Show SMILES CSCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O |r| Show InChI InChI=1S/C20H22N2O3S2/c1-26-13-11-14(20(24)25)21-19(23)10-12-22-15-6-2-4-8-17(15)27-18-9-5-3-7-16(18)22/h2-9,14H,10-13H2,1H3,(H,21,23)(H,24,25)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498792
(CHEMBL3623720)Show SMILES OC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O |r| Show InChI InChI=1S/C18H18N2O4S/c21-11-12(18(23)24)19-17(22)9-10-20-13-5-1-3-7-15(13)25-16-8-4-2-6-14(16)20/h1-8,12,21H,9-11H2,(H,19,22)(H,23,24)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035929
(CHEMBL3361082)Show InChI InChI=1S/C19H13NO3/c1-2-12-23-19(22)15-13-17(20-11-7-6-10-16(15)20)18(21)14-8-4-3-5-9-14/h1,3-11,13H,12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035921
(CHEMBL3361071)Show InChI InChI=1S/C17H12BrNO3/c1-10-3-2-4-14-13(17(21)22)9-15(19(10)14)16(20)11-5-7-12(18)8-6-11/h2-9H,1H3,(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035926
(CHEMBL3361079)Show SMILES Cc1cccc2c(cc(C(=O)c3ccc(Cl)cc3)n12)C(=O)NCC#C Show InChI InChI=1S/C20H15ClN2O2/c1-3-11-22-20(25)16-12-18(23-13(2)5-4-6-17(16)23)19(24)14-7-9-15(21)10-8-14/h1,4-10,12H,11H2,2H3,(H,22,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035928
(CHEMBL3361081)Show InChI InChI=1S/C20H16N2O2/c1-3-10-21-20(24)16-13-18(19(23)15-7-5-4-6-8-15)22-11-9-14(2)12-17(16)22/h1,4-9,11-13H,10H2,2H3,(H,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189296
(CHEMBL3827509)Show SMILES COc1cc(\C=C\C(=O)c2cc(C(O)=O)c3c(C)cc(C)cn23)cc(OC)c1OC Show InChI InChI=1S/C23H23NO6/c1-13-8-14(2)21-16(23(26)27)11-17(24(21)12-13)18(25)7-6-15-9-19(28-3)22(30-5)20(10-15)29-4/h6-12H,1-5H3,(H,26,27)/b7-6+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498786
(CHEMBL3623723)Show SMILES CSCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C20H21ClN2O3S2/c1-27-11-9-14(20(25)26)22-19(24)8-10-23-15-4-2-3-5-17(15)28-18-7-6-13(21)12-16(18)23/h2-7,12,14H,8-11H2,1H3,(H,22,24)(H,25,26)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50189298
(CHEMBL3826985)Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2cc(OC)c(OC)c(OC)c2)n2ccccc12 Show InChI InChI=1S/C23H23NO6/c1-5-30-23(26)16-14-18(24-11-7-6-8-17(16)24)19(25)10-9-15-12-20(27-2)22(29-4)21(13-15)28-3/h6-14H,5H2,1-4H3/b10-9+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
'Alexandru Ioan Cuza' University of Iasi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as... |
Bioorg Med Chem Lett 26: 3730-4 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.074 BindingDB Entry DOI: 10.7270/Q2DR2XFP |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035923
(CHEMBL3361068)Show InChI InChI=1S/C16H10BrNO3/c17-11-6-4-10(5-7-11)15(19)14-9-12(16(20)21)13-3-1-2-8-18(13)14/h1-9H,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035925
(CHEMBL3361066)Show InChI InChI=1S/C16H11NO3/c18-15(11-6-2-1-3-7-11)14-10-12(16(19)20)13-8-4-5-9-17(13)14/h1-10H,(H,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036273
(CHEMBL3361093)Show SMILES Cc1cccc2c(cc(C(=O)c3ccc(Cl)cc3)n12)C(=O)OCCC#C Show InChI InChI=1S/C21H16ClNO3/c1-3-4-12-26-21(25)17-13-19(23-14(2)6-5-7-18(17)23)20(24)15-8-10-16(22)11-9-15/h1,5-11,13H,4,12H2,2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035924
(CHEMBL3361067)Show InChI InChI=1S/C16H10ClNO3/c17-11-6-4-10(5-7-11)15(19)14-9-12(16(20)21)13-3-1-2-8-18(13)14/h1-9H,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035930
(CHEMBL3361084)Show InChI InChI=1S/C20H15NO3/c1-3-12-24-20(23)16-13-18(19(22)15-9-5-4-6-10-15)21-14(2)8-7-11-17(16)21/h1,4-11,13H,12H2,2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036275
(CHEMBL3361075)Show InChI InChI=1S/C19H14N2O2/c1-2-11-20-19(23)15-13-17(21-12-7-6-10-16(15)21)18(22)14-8-4-3-5-9-14/h1,3-10,12-13H,11H2,(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.21E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50035922
(CHEMBL3361070)Show InChI InChI=1S/C17H12ClNO3/c1-10-3-2-4-14-13(17(21)22)9-15(19(10)14)16(20)11-5-7-12(18)8-6-11/h2-9H,1H3,(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498785
(CHEMBL3623734)Show InChI InChI=1S/C17H17NO2S/c19-17(20-11-12-21)9-10-18-15-7-3-1-5-13(15)14-6-2-4-8-16(14)18/h1-8,21H,9-12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human FTase |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498788
(CHEMBL3623717)Show SMILES CSCC[C@H](NC(=O)CCn1c2ccccc2c2ccccc12)C(O)=O |r| Show InChI InChI=1S/C20H22N2O3S/c1-26-13-11-16(20(24)25)21-19(23)10-12-22-17-8-4-2-6-14(17)15-7-3-5-9-18(15)22/h2-9,16H,10-13H2,1H3,(H,21,23)(H,24,25)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498790
(CHEMBL3623722)Show SMILES CC(C)[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc12)C(O)=O |r| Show InChI InChI=1S/C20H22N2O3S/c1-13(2)19(20(24)25)21-18(23)11-12-22-14-7-3-5-9-16(14)26-17-10-6-4-8-15(17)22/h3-10,13,19H,11-12H2,1-2H3,(H,21,23)(H,24,25)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036278
(CHEMBL3361078)Show InChI InChI=1S/C20H16N2O2/c1-3-12-21-20(24)16-13-18(19(23)15-9-5-4-6-10-15)22-14(2)8-7-11-17(16)22/h1,4-11,13H,12H2,2H3,(H,21,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.78E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50498789
(CHEMBL3623715)Show SMILES OC(=O)[C@H](CS)NC(=O)CCn1c2ccccc2c2ccccc12 |r| Show InChI InChI=1S/C18H18N2O3S/c21-17(19-14(11-24)18(22)23)9-10-20-15-7-3-1-5-12(15)13-6-2-4-8-16(13)20/h1-8,14,24H,9-11H2,(H,19,21)(H,22,23)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human FTase using FPP/dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis |
Bioorg Med Chem Lett 25: 4447-52 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.008 BindingDB Entry DOI: 10.7270/Q2XS5ZDS |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50036271
(CHEMBL3361072)Show InChI InChI=1S/C17H13NO3/c1-11-7-8-18-14(9-11)13(17(20)21)10-15(18)16(19)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandru Ioan Cuza University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant farnesyltransferase using octyl-beta-D-glucopyranoside as substrate after 15 mins by fluorescence assay |
Bioorg Med Chem Lett 24: 5777-81 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.044 BindingDB Entry DOI: 10.7270/Q2W95BTK |
More data for this Ligand-Target Pair | |